All living cells encounter reactive oxygen species, which cause oxidative stress responses and changes in the cellular redox balance. Post-translational thiol-modifications of proteins play an important role in redox regulation of cellular metabolism and signal transduction processes to regulate antioxidant functions and redox homeostasis. Novel genetically encoded biosensors and redox proteomics tools allow to monitor the cellular redox state and the oxidation degree of thiol-switches at high spatiotemporal resolution in living cells across different organisms, which revealed the importance of redox changes for many cellular processes.

The study group aims to foster the scientific interactions and collaborations within the redox biology community in Germany. Another focus is the exchange of knowledge on the development of novel tools to study redox signaling processes and thiol-switches in different cells, compartments and tissues. The study group organizes biannual Redox biology meetings, which are performed on its own or as part of satellite meetings of GBM conferences. Members of the study group are also actively involved in organization of the biannual international EMBO workshop on Thiol-oxidation in biology.